Dipolar Order Relaxation Measurements of Lipid Membranes: Challenges of Jeener–Broekaert Experiments
Wallstein Niklas, Grélard Axelle, Girard Olivier M., Loquet Antoine, Pampel André, Duhamel Guillaume
Loquet Team NMR of Molecular Assemblies
Structural biology and biophysics by solid-state NMR spectroscopy
- Home unit: UMR5248 CBMN - www.cbmn.u-bordeaux.fr
Our research focuses on structural biology and biophysics of biological assemblies, ranging from functional amyloids to bacterial nanomachines and lipid membranes. We develop and mainly apply solid-state NMR spectroscopy to capture structural and dynamic details at atomic resolution.
Our group is part of the CBMN, a joint research unit of the CNRS, University of Bordeaux and Bordeaux INP. We manage the NMR platform of the IECB / CBMN, which is a part of the national network of high-field NMR Infranalytics Fr3050 CNRS.
Team Leader
- LOQUET Antoine
- CNRS Research Director, Unit Director UAR3033/US01
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Antoine Loquet graduated from the University of Lyon / Ecole Normale Supérieure de Lyon. He did his PhD (2006-2009) under the guidance of Anja Böckmann (IBCP Lyon), working on the development of Solid-State NMR to solve protein structures. In 2008 he joined the group of Beat Meier (ETH Zürich) to study prion fibrils by Solid-State NMR. He then focused his research on molecular assemblies by Solid-State NMR as an EMBO postdoctoral fellow with Adam Lange at the Max Planck Institute for Biophysical Chemistry (Göttingen, Germany). There, he developed Solid-State NMR methods to determine atomic structures of large biological supramolecular assemblies.
He obtained a CNRS position in 2013 at the CBMN (Institute of Chemistry & Biology of Membranes & Nanoobjects) in Bordeaux and obtained a Research Director position in 2020. In 2014, he was recruited as a group leader at the IECB and since 2016, he is leading the group « NMR of Membranes and Protein Assemblies » at CBMN. Deputy Director of IECB (2021-2023). Director of the Unit UAR3033/US01 IECB since Sep. 2024.
The group aims at investigating 3D atomic structures, assembly processes and molecular interactions of biological systems, including functional amyloids, bacterial appendages and membrane proteins. We develop and apply solid-state NMR to capture structural and dynamic details at the atomic scale. Our work is funded by the ERC, ANR, IdEx-Bordeaux and industrial contracts.
People
CNRS Postdoctoral researcher (PI: B. Habenstein)
CNRS research engineer
CNRS PhD student
UB PhD student
Emeritus research director
CNRS PhD student
CNRS researcher
CNRS engineer
CNRS research engineer
CNRS Research Director
CNRS Postdoctoral researcher
CNRS PhD student (PI: B. Habenstein)
CNRS PhD student (PI: B. Habenstein)
CNRS PhD student
UB associate professor
CNRS engineer (PI: B. Habenstein)
Latest publications
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Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Burger Domenic, Kashyrina Marianna, van den Heuvel Lukas, de la Seiglière Hortense, Lewis Amanda J, de Nuccio Francesco, Mohammed Inayathulla, Verchère Jérémy, Feuillie Cécile, Berbon Mélanie, Arotcarena Marie-Laure, Retailleau Aude, Bezard Erwan, Canron Marie-Hélène, Meissner Wassilios G, Loquet Antoine, Bousset Luc, Poujol Christel, Nilsson K. Peter R., Laferrière Florent, Baron Thierry, Lofrumento Dario Domenico, de Giorgi Francesca, Stahlberg Henning, Ichas François
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Aspergillus fumigatus effector crpA orchestrates host prostaglandin signaling to promote fungal virulence
Pinzan Camila Figueiredo, Diehl Camila, de Castro Patrícia Alves, Delbaje Endrews, Rocha Peter, Marciano Camila Langer, da Rosa-Garzon Nathalia Gonsales, Cabral Hamilton, Sprute Rosanne, Kolovou Androniki, Vilela Adriana Ferreira Lopes, Sorgi Carlos Arterio, Ecoutin Agathe, Berbon Mélanie, Loquet Antoine, Freitas-Filho Edismauro Garcia, Cunha Larissa Dias, Thrikawala Savini, Rosowski Emily, dos Reis Thaila Fernanda, Goldman Gustavo