The amyloidogenic C-terminal region of TMEM106B modulates lipid membrane biophysical properties: Functional and pathological insights
Berbon Mélanie, Grélard Axelle, Bataille Laure, El Mammeri Nadia
BERBON Mélanie
- CNRS research engineer
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Home unit: UMR5248 CBMN
www.cbmn.u-bordeaux.fr - 0540003031
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Research on macromolecular assemblies involved in biological processes such as programmed cell death (functional amyloids) or execution of bacterial or viral infection (tubes, pilus, filaments).
I have set up the bacterial overexpression of isotopically labeled proteins (U13C15N- selectively 13C, deuterated and per-deuterated, methyl specific labeling... ) and their in vitro self-assembly for solid-state NMR analysis. At present, I am supervising the sample production activities, being in charge of the training of new team members and the implementation and optimisation of sample production conditions for new projects.
CIS display selection, production and purification of therapeutic peptides.
Phage display selection, production and purification of therapeutic antibodies.
Biography
- since 2024 Research Engineer CNRS, CBMN UMR5248 Pessac (France)
- 2015-2024 Engineer CNRS, CBMN UMR5248 Pessac (France)
- 2013-2014 Engineer CNRS, IBL UMR 8161, LIlle (France)
- 2013 ISOGENICA Ltd, Cambridge (UK)
- 2011-2012 NOVARTIS Research, Basel (Switzerland)
- 2011 Graduated from the National School of Technology of Biomolecules (ENSTBB), Bordeaux (France)
Latest publications
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Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Burger Domenic, Kashyrina Marianna, van den Heuvel Lukas, de la Seiglière Hortense, Lewis Amanda J, de Nuccio Francesco, Mohammed Inayathulla, Verchère Jérémy, Feuillie Cécile, Berbon Mélanie, Arotcarena Marie-Laure, Retailleau Aude, Bezard Erwan, Canron Marie-Hélène, Meissner Wassilios G, Loquet Antoine, Bousset Luc, Poujol Christel, Nilsson K. Peter R., Laferrière Florent, Baron Thierry, Lofrumento Dario Domenico, de Giorgi Francesca, Stahlberg Henning, Ichas François
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Aspergillus fumigatus effector crpA orchestrates host prostaglandin signaling to promote fungal virulence
Pinzan Camila Figueiredo, Diehl Camila, de Castro Patrícia Alves, Delbaje Endrews, Rocha Peter, Marciano Camila Langer, da Rosa-Garzon Nathalia Gonsales, Cabral Hamilton, Sprute Rosanne, Kolovou Androniki, Vilela Adriana Ferreira Lopes, Sorgi Carlos Arterio, Ecoutin Agathe, Berbon Mélanie, Loquet Antoine, Freitas-Filho Edismauro Garcia, Cunha Larissa Dias, Thrikawala Savini, Rosowski Emily, dos Reis Thaila Fernanda, Goldman Gustavo