Pseudo-Phosphorylated Tau Forms Paired Helical Filaments in the Presence of High-Curvature Cholesterol-Containing Lipid Membranes
El Mammeri Nadia, Duan Pu, Hong Mei
EL MAMMERI Nadia
- CNRS researcher
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Home unit: UMR5248 CBMN
www.cbmn.u-bordeaux.fr - 0540003029
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Institute of Chemistry and Biology of Membranes and Nano-objects
My research explores the molecular structures and assembly mechanisms of biomolecular aggregates at the atomic scale, with a particular emphasis on the transmembrane lysosomal protein TMEM106B, which is implicated in aging and neurological disorders. I primarily use and develop solid-state NMR techniques, complemented by cryo-EM, solution NMR, and other biophysical approaches, to elucidate how these aggregates form and function.
Biography
2025-present Charge de Recherche CNRS
CBMN/IECB – Pessac, France – Université de Bordeaux
"Chemical code of the TMEM106B protein in its functional and pathological states”
2021-2024 Postdoctoral Associate
MIT – Cambridge, MA, USA – Department of Chemistry - Professor Mei Hong
"Structure and Dynamics of the Tau protein in its functional and pathological states"
2019-2020 Visiting Student Researcher - Fulbright
Yale University – School of Medicine – Microbial Pathogenesis - Professor Jorge E. Galán
"Structural study of the inner rod protein of the type III secretion system of Salmonella typhimurium"
2017-2020 Doctoral degree– Doctoral School of Chemical Sciences
“Structural investigations of supramolecular assemblies using solid-state NMR”
CBMN/IECB – Pessac, France – Université de Bordeaux
"Chemical code of the TMEM106B protein in its functional and pathological states”
2021-2024 Postdoctoral Associate
MIT – Cambridge, MA, USA – Department of Chemistry - Professor Mei Hong
"Structure and Dynamics of the Tau protein in its functional and pathological states"
2019-2020 Visiting Student Researcher - Fulbright
Yale University – School of Medicine – Microbial Pathogenesis - Professor Jorge E. Galán
"Structural study of the inner rod protein of the type III secretion system of Salmonella typhimurium"
2017-2020 Doctoral degree– Doctoral School of Chemical Sciences
“Structural investigations of supramolecular assemblies using solid-state NMR”
Latest publications
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Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer’s disease fold
Duan Pu, El Mammeri Nadia, Hong Mei
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Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation
Mammeri Nadia El, Dregni Aurelio, Duan Pu, Hong Mei