11AM
The next IECB monthly seminar will be held on February 7th at 11:00 AM.
The speaker, Professor Sabine L Flitsch from the MIB & Department of Chemistry, University of Manchester (UK), will present a seminar entitled: Enzyme cascades for organic synthesis.
The combination of sequential biocatalytic reactions in non-natural synthetic cascades is a rapidly developing field and leads to the generation of complex valuable chemicals from simple precursors [1]. By using biocatalysis under physiological conditions in water, many parameters that are considered as green and sustainable chemistry are met. As the toolbox of available biocatalysts continues to expand, so do the options for biocatalytic retrosynthesis of a target molecule, leading to new routes employing enzymatic transformations. To facilitate the design stage, we have established RetroBioCat, a computer-aided synthesis planning tool for biocatalytic reactions and cascades [2]. The implementation of such cascade reactions requires careful consideration, particularly with respect to whether the pathway is constructed in vitro or in vivo, in batch format or in flow [3]. This lecture will showcase several successful de novo cascades and discuss the relative merits of in vitro, in vivo or hybrid approaches to building biocatalytic cascades [4]. These cascades incorporate alcohol oxidations [5,6], C-H- activations [7] and acylations via acyl-phosphates [8] and thioesters [9].
References
1.- Bell, E. L. et al. (2021) Nature Review Methods Primers 1, 46.
2.- Finnigan, W. et al. (2021) Nature Catalysis 4, 98; (2023) ACS Catalysis 13 (17). 11771.
3.- Mattey, A. P. et al. (2021) Angew. Chem. Int. Ed. 60, 18660.
4.- France, S. P. et al. (2017) ACS Catalysis 7, 710.
5.- Ford, G. J. et al. (2022) JACS Au 2, 2251.
6.- Swanson, C. R. B. et al. (2023) ACS Central Science 9, 103.
7.- Manning, J. et al. (2019) Angew. Chem. Int. Ed. 58, 5668.
8.- Lubberink, M. et al. (2022) Angew. Chem. Int. Ed. 61, e202205054; (2023) Green Chemistry 25 (8) 2958.
9.- Schnepel, C. et al. (2023) Nature Catalysis 6, 89.

Contact
- FRISCOURT Frederic - UB associate professor
- 0540003371
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