Services and expertise

• Synthesis or process verification, either with low resolution or with accurate mass measurement of small molecules (polyphenols, lipids, antimicrobial molecules, various synthetic compounds,…) and biomolecules (peptides, proteins and nucleic acids)
• Elementary composition determination (via the accurate mass) for small molecules (M < 1000 Da)
• Fragmentation spectra for structural elucidation of small molecules
• Native Mass Spectrometry: investigation of non-covalent complexes (stoichiometry determination, relative quantification, detection of minor complexes in mixtures).
• Ligand binding analysis. We design mass spectrometry experiments to characterize ligand binding to biomolecule or biomimetics targets, for ligand binding equilibrium constants (KD) determination, or monitor complex formation (min time scale and longer).

Equipment

• Agilent 6560 ESI-IMS-Q-TOF : High resolution drift tube ion mobility, ESI, QTOF
• Waters Q-TOF Ultima Global : optimized for non-covalent complexes
• Waters LCT Premier : optimized for large masses
• Thermo Exactive orbitrap
• 2 Thermo LCQ Advantage : available for external users 50% of its operation time
• Agilent 6230 ESI-TOF : UHPLC / MS

Agilent 6560 ESI-IMS-Q-TOF, the first drift tube ion mobility spectrometer available in plateform in Europe!

Access

For any analytical experiment with assistance or free access, or for a R&D project, please ask the facility engineers for a detailed quotation.

Technical contacts

Manager: Frédéric Rosu: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Technician: Loïc Klinger: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Scientific expertise

Valérie Gabelica: This e-mail address is being protected from spambots. You need JavaScript enabled to view it