Unusual Nucleic Acid structures




Nucleic acids are prone to structural polymorphism: in addition to the well known DNA double-helix, a number of alternative structures may be formed. Several genetic diseases are mediated by the formation of non-B DNA structures at certain chromosomal locations. Among these oddities, a family of nucleic acid secondary structures known as G-quadruplexes (G4) has emerged as more than a novelty. These structures can be formed by certain guanine-rich sequences and are stabilized by G-quartets. The evidence for quadruplex formation in vivo is compelling. Our goals are now to conceive and validate new biochemical, bioinformatic, and physico-chemical tools (compounds, aptamers, tests, physical properties tables…) to demonstrate that G4 DNA or RNA is (or is not!) involved in particular biological functions.


A quartet (left) and quadruplexes (right)

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Zhou, J. et al.  (2013) Angew. Chem., in press.

Leung, K.H. et al.  (2013) Chem. Comm., in press.

Castillo-Gonzalez et al. (2013) Curr Pharm. Des., 19: 2164-73

He, H.Z. et al.  (2013) Biosensors & Bioelectr., Vol. 41: 871-4

Tran, P.L.T. et al.  (2012) Top. Curr. Chem. Vol. 330: 243-73

Petenzi, M. et al.  (2012) Chem. Eur. J., Vol. 18: 14487-96

Smith, N. et al.  (2012) Chem. Comm., Vol. 48: 11464-6

Zhou, J. et al.  (2012) Angew Chem., Vol. 51: 11002-5

Renciuk, D. et al.  (2012) Methods, Vol. 57: 122-128

Ma, D.L. et al. (2012) Anal. Chimica Acta, Vol. 733: 78-83

Mergny, J.L. (2012) Biochimie, Vol. 94: 1261

Amrane, S. et al.  (2012) JACS, Vol. 134: 5807-16

Nicoludis, J.M. et al.  (2012) NAR Vol. 40: 5432-47.

Guittet et al. (2012) NAR Vol. 40: 5162-70

Mergny, J.L. (2012) Nature Chem. Biol. Vol. 8: 225-6.

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