Cells grow and divide in a controlled fashion via a regulated series of events termed the cell cycle.  Extensive structural rearrangements occur during the cell cycle that facilitate the efficient partitioning of the duplicated genome into a daughter cell.  We study how cell cycle cues elicit these structural transitions at the molecular and cell biological level.  In doing so, our aim is to understand how cell growth and cell division are coordinated, and how failure of these mechanisms contributes to cancer.