48mer quinolinecarboxamide crystal structure

The Ivan Huc Group

Our group has developed a unique know-how in the design, synthesis and characterization of artificial folded molecular architectures (foldamers) based on aromatic oligoamides. These objects differ notably from peptides or nucleotides, from which they are inspired, and from their analogues, and give access to structural motifs and thus to functions beyond those of biopolymers.

Our main research lines include the development of synthetic and design methodologies towards molecular objects as large and complex as small proteins ; the investigation of receptors and molecular motors based on these folded architectures ; the study of potential biological applications of aromatic oligoamide foldamers, in particular to recognize protein surfaces ; and exploration of properties such as electron transport which may be of use in new materials. These projects have fostered a very active collaboration with x-ray crystallographers and our involvement in the set-up of an x-ray diffraction facility.

IECB - Institut Européen de Chimie et Biologie

We are affiliated to the CBMN Laboratory, a joint research unit of the CNRS, the University of Bordeaux, and the Bordeaux Polytechnic Institute. Our laboratory space is embedded in the European Institute of Chemistry and Biology, a research team incubator that promotes emergence and interdisciplinary research on the University of Bordeaux campus.

News

04/11/2014

Bordeaux 2015 Symposium on Foldamers

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02/07/2014

Cover picture : EJOC 2014, 4265

Check out last cover picture for Simon's paper ! Read more
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Latest publications

S. Müller, K. Laxmi-Reddy, P. V. Jena, B. Baptiste, Z. Dong, F. Godde, T. Ha, R. Rodriguez, S. Balasubramanian, I. Huc*
Targeting DNA G-Quadruplexes with Helical Small Molecules
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M. L. Singleton, G. Pirotte, B. Kauffmann, Y. Ferrand, I. Huc*
Increasing the size of an aromatic helical foldamer cavity by strand intercalation
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J. Shang, Q. Gan, S. J. Dawson, F. Rosu, H. Jiang, Y. Ferrand*, I. Huc*
Self-​association of aromatic oligoamide foldamers into double helices in water
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