48mer quinolinecarboxamide crystal structure

The Ivan Huc Group

Our group has developed a unique know-how in the design, synthesis and characterization of artificial folded molecular architectures (foldamers) based on aromatic oligoamides. These objects differ notably from peptides or nucleotides, from which they are inspired, and from their analogues, and give access to structural motifs and thus to functions beyond those of biopolymers.

Our main research lines include the development of synthetic and design methodologies towards molecular objects as large and complex as small proteins ; the investigation of receptors and molecular motors based on these folded architectures ; the study of potential biological applications of aromatic oligoamide foldamers, in particular to recognize protein surfaces ; and exploration of properties such as electron transport which may be of use in new materials. These projects have fostered a very active collaboration with x-ray crystallographers and our involvement in the set-up of an x-ray diffraction facility.

IECB - Institut Européen de Chimie et Biologie

We are affiliated to the CBMN Laboratory, a joint research unit of the CNRS, the University of Bordeaux, and the Bordeaux Polytechnic Institute. Our laboratory space is embedded in the European Institute of Chemistry and Biology, a research team incubator that promotes emergence and interdisciplinary research on the University of Bordeaux campus.

News

30/06/2016

Congratulation to Xiang for successfully defending his PhD thesis

Dr Xiang Wang successfully completed and defended his PhD last tuesday Read more
14/04/2016

Symposium on Foldamers 2016

We are pleased to announce that registration is now open to attend the Bordeaux 2016 Symposium on Foldamers which will take place at the European Institute of Chemistry and Biology, on the campus of the University of Bordeaux, France, on September 26-28 2016. Read more
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Latest publications

P. K. Mandal, B. Kauffmann, H. Destecroix, Y. Ferrand,
A. P. Davis*, I. Huc*

Crystal structure of a complex between b-glucopyranose and a macrocyclic receptor with dendritic multicharged water solubilizing chains
See the publication
P. K. Mandal, G. W. Collie, S. C. Srivastava, B. Kauffmann, I. Huc*
Structure elucidation of the Pribnow box consensus promoter sequence by racemic DNA crystallography
See the publication
M. Kudo, D. Carbajo López, V. Maurizot, H. Masu,
A. Tanatani,* I. Huc*

Synthesis and conformational analysis of quinoline–oxazole peptides
See the publication