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The synthesis of ellagitannins reviewed by the Quideau team

The synthesis of ellagitannins reviewed by the Quideau team

IECB team leader Stéphane Quideau and his team study the chemistry of ellagitannins, a class of plant polyphenols whose biological activities may lead to therapeutic applications against cancer, osteoporosis and viral diseases.  In a review released in April 2011 in Natural Products Reports (cover on the left), they provide a detailed overview of chemical synthesis approaches to these natural products.

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Vescalagin causes the collapse of the actin cytoskeleton

Vescalagin causes the collapse of the actin cytoskeleton

Following an internal call for proposals launched by IECB in 2007 to stimulate interdisciplinary interactions, the Génot and Quideau teams initiated a collaboration on the effect of vescalagin, an ellagitannin extracted from oak wood, upon actin. Their results, which have just been published in Angewandte Chemie International Edition, could lead to a novel therapy against osteoporosis. The two teams submitted an application to patent their discovery.

On the left: Vescalagin winds actins filaments into fibrillar aggregates

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Tethered by monkeytail

Tethered by monkeytail

IECB team leader Dr. Cameron Mackereth, through interdisciplinary research with the group of Sébastien Fribourg, discovers that Rna14p and Rna15p, two proteins which contribute to messenger RNA maturation in yeast, are tethered by cooperative folding of two peptides: the hinge domain and the monkeytail domain.

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Annexin-A5: a protein that promotes cell membrane repair

 

Annexin-A5: a protein that promotes cell membrane repair

Alain Brisson and its team from the IECB demonstrate in a paper released on April 5 in Nature Communications that Annexine-A5 plays a central role in the cell membrane repair machinery.

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A new team leader in molecular and cellular biology

A new team leader in molecular and cellular biology

How does the cell divide when its genome is damaged? This is one of the research interests of Dr. Anne Royou, a new team leader who joined the institute in March 2011. Her team, “Control and dynamics of cell division”, which is affiliated to the Institut de Biochimie et Génétique Cellulaires (IBGC) of Bordeaux, will be first hosted at IECB for a probative period of three years.  

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