Publications

2009-present |  before | 

    2009-present

  1. Reinhold, W.C., Mergny, J.L., Liu, H., Ryan, M., Pfister, T.D., Kinders, R., Parchment, R., Doroshow, J., Weinstein, J.N., Pommier, Y. (2010) Transcriptional regulation of TOP1 in relationship with transcription pausing at guanosine quartets, DNA copy number, and genomic instability. Cancer Res. in press.

  2. Monchaud, D., Granzhan, A., Saettel, N., Guédin, A., Mergny, J.L., Teulade-Fichou, M.P. (2010) "One ring to bind them all" Part 1: The efficiency of the macrocyclic scaffold for G-quadruplex DNA recognition J. Nucleic Acids submitted.

  3. Marcel, V., Tran, P.L.T., Fernet, M., Sagne, C., Martel-Planche, G., Vaslin, L., Teulade-Fichou, M.P., Hall, J., Mergny, J.L., Hainaut, P., Van Dyck, E. (2010) G-quadruplex structures in TP53 gene are involved in the splicing of intron 2, in preparation.

  4. Guédin, A., Lacroix, L., Mergny, J.L. (2010) Thermal melting studies of ligand DNA interactions. Methods Mol. Biol. 613, 25-35.

  5. Granzhan, A., Monchaud, D., Saettel, N., Guédin, A., Mergny, J.L., Teulade-Fichou, M.P. (2010) "One ring to bind them all" Part 2: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-type Macrocycles. J. Nucleic Acids submitted.

  6. Yang, P., De Cian, A., Teulade-Fichou, M.P., Mergny, J.L., Monchaud, D. (2009) Engineering Bisquinolinium-Thiazole Orange Conjugates for Fluorescent Sensing of G-quadruplex DNA. Angew. Chem. Int. Ed. 48, 2188-2191.

  7. Stegle, O., Payet, L., Mergny, J.L., macKayy, D.J.C., Huppert, J. (2009) Predicting and understanding the stability of G-quadruplexes. Bioinformatics 25, i374-i382.

  8. Ribeyre, C., Lopes, J., Boulé, J.-B., Piazza, A., Guédin, A., Zakian, V.A., Mergny, J.-L., Nicolas, A. (2009) The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex -Forming CEB1 Sequences in vivo. PLoS Genet. 5, e1000475.

  9. Mergny, J.L., Lacroix, L. (2009) UV melting of G-quadruplexes. Curr. Protocols Nucl. Acids Chem. 17, 17.11.11-17.11.15.

  10. Mendez-Bermudez, A., Hills, M., Pickett, H.A., Phan, A.T., Mergny, J.L., Riou, J.F., Royle, N. (2009) Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and in the male germline. Nucleic Acids Res. 37, 6225-6238.

  11. Lim, K.W., Alberti, P., Guédin, A., Lacroix, L., Riou, J.F., Royle, N., Mergny, J.L., Phan, A.T. (2009) Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a GCGC tetrad Nucleic Acids Res. 37, 6239-6248.

  12. Guédin, A., Alberti, P., Mergny, J.L. (2009) Stability of intramolecular quadruplexes: sequence effects in the central loop. Nucleic Acids Res. 37, 5559-5567.

  13. El Bakali, J., Klupsch, F., Guedin, A., Brassart, B., Fontaine, G., Farce, A., Roussel, P., Houssin, R., Bernier, J.L., Chavatte, P., Mergny, J.L., Riou, J.F., Henichart, J.P. (2009) 2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers. Bioorg. Med. Chem. Lett. 19, 3434-3438. online Access

  14. Bertrand, H., Bombard, S., Monchaud, D., Talbot, E., Guédin, A., Mergny, J.L., Grünert, R., Bednarski, P.J., Teulade-Fichou, M.P. (2009) Exclusive platination of loop adenines in the human telomeric G-quadruplex Org. Biomol. Chem. 7, 2864-2871.

    15. before 2009

  15. Rosu, F., Gabelica, V., De Pauw, E., Mailliet, P., Mergny, J.L. (2008) Cooperative 2:1 binding of a bisphenothiazine to duplex DNA. ChemBioChem 9, 849-852. online Access

  16. Monchaud, D., Yang, P., Lacroix, L., Teulade-Fichou, M.P., Mergny, J.L. (2008) A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity. Angew. Chem. Int. Ed. 57, 4858-4861.

  17. Monchaud, D., Allain, C., Bertrand, H., Smargiasso, N., Rosu, F., Gabelica, V., De Cian, A., Mergny, J.L., Teulade-Fichou, M.P. (2008) Ligands playing musical chairs with G-quadruplex DNA: a rapid and simple displacement assay for identifying selective G-quadruplex binders. Biochimie 90, 1207-1223.

  18. Mills, M., Mergny, J.L., Klump, H.H. (2008) From quadruplex to helix and back: meta-stable states can move through a cycle of conformational changes. Arch. Biochem. Biophys. 474, 8-14. online Access

  19. Mergny, J.L. (2008) Quadruplexes. What else ? . Collection Symposium Series (M. Hocek, Ed.) 10, 80-86.

  20. Lyonnais, S., Pietrement, O., Chepelianski, A., Gueron, S., Lacroix, L., Le Cam, E., Mergny, J.L. (2008) Functionalization of DNA G-Wires for patterning and nanofabrication. Nucleic Acids Symp Ser (Oxf) 689-690. online Access

  21. Guittat, L., Mergny, J.L. (2008) Telomerase inhibition : strategies and protocols. A book review. ChemMedChem 3, 1135-1137.

  22. Guédin, A., De Cian, A., Gros, J., Lacroix, L., Mergny, J.L. (2008) Sequence effects in single base loops for quadruplexes. Biochimie 90, 686-696.

  23. Gros, J., Guédin, A., Mergny, J.L., Lacroix, L. (2008) G-quadruplex formation interferes with P1 helix formation in the RNA component of telomerase hTERC. ChemBioChem 9, 2075-2078.

  24. Gros, J., Avino, A., Lopez de la Osa, J., Gonzalez, C., Lacroix, L., Perez, A., Orozco, M., Eritja, R., Mergny, J.L. (2008) 8-Amino guanine accelerates tetramolecular G-quadruplex formation. Chem. Comm. 2008, 2926-2928. online Access

  25. De Cian, A., Lacroix, L., Douarre, C., Temime-Smaali, N., Trentesaux, C., Riou, J.F., Mergny, J.L. (2008) Targeting Telomeres and Telomerase. Biochimie 90, 131-155.

  26. De Cian, A., Gros, J., Guedin, A., Haddi, M., Lyonnais, S., Guittat, L., Riou, J.F., Trentesaux, C., Sacca, B., Lacroix, L., Alberti, P., Mergny, J.L. (2008) DNA and RNA quadruplex ligands. Nucleic Acids Symp Ser (Oxf) 7-8. online Access

  27. De Cian, A., Grellier, P., Mouray, E., Depoix, D., Bertrand, H., Monchaud, D., Teulade-Fichou, M.P., Mergny, J.L., Alberti, P. (2008) Plasmodium telomeric sequences: structure, stability and quadruplex targeting by small compounds. ChemBioChem 9, 2730-2739.

  28. Cheng, M.K., Modi, C., Cookson, J.C., Hutchinson, I., Heald, R.A., McCarroll, A.J., Missailidis, S., Tanious, F., Wilson, W.D., Mergny, J.L., Laughton, C.A., Stevens, M.F. (2008) Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13- dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents. J. Med. Chem. 51, 963-975. online Access

  29. Chaires, J.B., Mergny, J.L. (2008) Targeting DNA. Biochimie 90, 973-975.

  30. Amrane, S., De Cian, A., Rosu, F., Kaiser, M., De Pauw, E., Teulade-Fichou, M.P., Mergny, J.L. (2008) Identification of trinucleotide repeat ligands with a FRET melting assay. ChemBioChem 9, 1229-1234. online Access

  31. Mergny, J.L., Lacroix, L., Riou, J.F. (2007) Telomerase: a dimeric menage a trois. ChemBioChem 8, 1483-1485. online Access

  32. Hounsou, C., Guittat, L., Monchaud, D., Jourdan, M., Saettel, N., Mergny, J.L., Teulade-Fichou, M.P. (2007) G-quadruplex recognition by quinacridines: a SAR, NMR and biological study. ChemMedChem 2, 655-666.

  33. Gros, J., Rosu, F., Amrane, S., De Cian, A., Gabelica, V., Lacroix, L., Mergny, J.L. (2007) Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes. Nucleic Acids Res. 35, 3064-3075.

  34. De Cian, A., Mergny, J.L. (2007) Quadruplex ligands act as molecular chaperones for tetramolecular quadruplex formation. Nucleic Acids Res. 35, 2483-2493.

  35. De Cian, A., Guittat, L., Kaiser, M., Saccà, B., Amrane, S., Bourdoncle, A., Alberti, P., Teulade-Fichou, M.P., Lacroix, L., Mergny, J.L. (2007) Fluorescence-based melting assays for studying quadruplex ligands. Methods 42, 183-195.

  36. De Cian, A., DeLemos, E., Mergny, J.L., Teulade-Fichou, M.P., Monchaud, D. (2007) Highly Efficient G-Quadruplex Recognition by Bisquinolinium Compounds. J. Am. Chem. Soc. 129, 1856-1857.

  37. De Cian, A., Cristofari, G., Reichenbach, P., De Lemos, E., Monchaud, D., Teulade-Fichou, M.P., Shin-Ya, K., Lacroix, L., Lingner, J., Mergny, J.L. (2007) Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action. Proc. Natl. Acad. Sci. USA 104, 17347-17352. online Access

  38. Brassart, B., Gomez, D., De Cian, A., Paterski, R., Montagnac, A., Qui, K.H., Temime-Smaali, N., Trentesaux, C., Mergny, J.L., Gueritte, F., Riou, J.F. (2007) A new steroid derivative stabilizes G-quadruplexes and induces telomere uncapping in human tumor cells. Mol. Pharmacol. 72, 631-640. online Access

  39. Bertrand, H., Monchaud, D., De Cian, A., Guillot, R., Mergny, J.L., Teulade-Fichou, M.P. (2007) The importance of metal geometry in the recognition of G-quadruplex DNA by metal-terpyridine complexes. Org. Biomol. Chem. 5, 2555-2559.

  40. Bates, P., Mergny, J.L., Yang, D. (2007) Quartets in G-major. The First International Meeting on Quadruplex DNA. EMBO Rep. 8, 1003-1010. online Access

  41. Romero-Salas, T., Petruseva, I., Lavrik, O., Bourdoncle, A., Mergny, J.-L., Favre, A., Saintome, C. (2006) Human Replication Protein A unfolds telomeric G-quadruplexes. Nucleic Acids Res. 34, 4857-4865.

  42. Mergny, J.L., De Cian, A., Amrane, S., Webba da Silva, M. (2006) Kinetics of double-chain reversals bridging contiguous quartets in tetramolecular quadruplexes. Nucleic Acids Res. 34, 2386-2397. online Access

  43. Kaiser, M., De Cian, A., Sainlos, M., Renner, C., Mergny, J.L., Teulade-Fichou, M.P. (2006) Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition. Org. Biomol. Chem. 4, 1049-1057. online Access

  44. Bourdoncle, A., Estévez-Torres, A., Gosse, C., Lacroix, L., Vekhoff, P., Le Saux, T., Jullien, L., Mergny, J.L. (2006) Quadruplex-based Molecular Beacons as Tunable DNA Probes. J. Am. Chem. Soc. 128, 11094-11105.

  45. Amrane, S., Mergny, J.L. (2006) Length and pH-dependent energetics of (CCG)(n) and (CGG)(n) trinucleotide repeats. Biochimie 88, 1125-1134. online Access

  46. Alberti, P., Bourdoncle, A., Saccà, B., Lacroix, L., Mergny, J.L. (2006) DNA nanomachines and nanostructures involving quadruplexes. Org. Biomol. Chem. 4, 3383-3391.

  47. Saccà, B., Lacroix, L., Mergny, J.L. (2005) The effect of chemical modifications on the thermal stability of different G-quadruplexes-forming oligonucleotides. Nucleic Acids Res. 33, 1182-1192.

  48. Riou, J.F., Gomez, D., Mergny, J.L., Guittat, L., Paterski, R., Chenais, B., Morjani, H., Trentesaux, C. (2005) Régulation de la longueur des télomères: rendre la télomérase accessible. Bull. Cancer 92, 13-22.

  49. Pennarun, G., Granotier, C., Gauthier, L.R., Gomez, D., Hoffschir, F., Mandine, E., Riou, J.F., Mergny, J.L., Mailliet, P., Boussin, F.D. (2005) Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene 24, 2917-2928.

  50. Mergny, J.L., Li, J., Lacroix, L., Amrane, S., Chaires, J.B. (2005) Thermal Difference Spectra: a specific signature for nucleic acid structures. Nucleic Acids Res. 33, e138.

  51. Mergny, J.L., De Cian, A., Ghelab, A., Saccà, B., Lacroix, L. (2005) Kinetics of tetramolecular quadruplexes. Nucleic Acids Res. 33, 81-94.

  52. Guittat, L., DeCian, A., Rosu, F., Gabelica, V., DePauw, E., Delfourne, E., Mergny, J.L. (2005) Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro. Bioch. Biophys. Acta Gen. Subjects 1724, 375-384.

  53. Gros, J., Webba da Silva, M., De Cian, A., Amrane, S., Rosu, F., Bourdoncle, A., Saccà, B., Alberti, P., Lacroix, L., Mergny, J.L. (2005) Kinetics and thermodynamics of G-quadruplexes. Nucleic Acids Symp. Series 49, 61-62.

  54. Granotier, C., Pennarun, G., Riou, L., Hoffschir, F., Gauthier, L.R., De Cian, A., Gomez, D., Mandine, E., Riou, J.F., Mergny, J.L., Mailliet, P., Dutrillaux, B., Boussin, F.D. (2005) Preferential binding of a G-quadruplex ligand to human chromosome ends. Nucl Acid Res 33, 4182-4190.

  55. Garestier, T., Arimondo, P., Mergny, J.L. (2005) The chemistry and biology of small molecules acting on nucleic acids: Foreword. Curr. Med. Chem. Anti Cancer Agents 5, 317-319.

  56. De Cian, A., Guittat, L., Riou, J.F., Shin-ya, K., Mergny, J.L. (2005) Affinity and selectivity of G4 ligands measured by FRET. Nucleic Acids Symp. Series 49, 61-62.

  57. Amrane, S., Saccà, B., Mills, M., Chauhan, M., Klump, H.H., Mergny, J.L. (2005) Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats. Nucleic Acids Res. 33, 4065-4077.

  58. Horn, V., Lacroix, L., Gautier, T., Takasugi, M., Mergny, J.L., Lacoste, J. (2004) Triple helix formation with Drosophila satellite repeats. Unexpected stabilization by copper ions. Biochemistry 43, 11196-11205.

  59. Guittat, L., Alberti, P., Gomez, D., De Cian, A., Pennarun, G., Lemarteleur, T., Belmokhtar, C., Paterski, R., Morjani, H., Trentesaux, C., Mandine, E., Boussin, F., Mailliet, P., Lacroix, L., Riou, J.-F., Mergny, J.-L. (2004) Targeting human telomerase for cancer therapeutics. Cytotechnology 45, 75-90.

  60. Gomez, D., Paterski, R., Lemarteleur, T., Shin-ya, K., Mergny, J.L., Riou, J.F. (2004) Interaction of telomestatin with the telomeric single-strand overhang. J. Biol. Chem. 279, 41487-41494.

  61. Gomez, D., Lemarteleur, T., Lacroix, L., Mailliet, P., Mergny, J.L., Riou, J.F. (2004) Telomerase down regulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic Acids Res. 32, 371-379.

  62. Alberti, P., Mergny, J.L. (2004) DNA structural changes as the basis for a nanomolecular device. Cell. Mol. Biol. 50, 241-253.

  63. Teulade-Fichou, M.P., Hounsou, C., Guittat, L., Mergny, J.L., Alberti, P., Carrasco, C., Bailly, C., Lehn, J.M., Wilson, W.D. (2003) Molecular recognition of quadruplex DNA by quinacridine derivatives. Nucleos. Nucleot. Nucleic Acids 22, 1483-1485.

  64. Teulade-Fichou, M.P., Carrasco, C., Guittat, L., Bailly, C., Alberti, P., Mergny, J.L., David, A., Lehn, J.M., Wilson, W.D. (2003) Selective recognition of G-quadruplex telomeric DNA by a bis(Quinacridine) macrocycle. J. Am. Chem. Soc. 125, 4732-4740.

  65. Rosu, F., Pauw, E.D., Guittat, L., Alberti, P., Lacroix, L., Mailliet, P., Riou, J.-F., Mergny, J.-L. (2003) Selective interaction of ethidium derivatives with quadruplexes: an equilibrium dialysis and electrospray ionization mass spectrometry analysis. Biochemistry 42, 10361-10371.

  66. Mergny, J.L., Lacroix, L. (2003) Analysis of thermal melting curves. Oligonucleotides 13, 515-537.

  67. Lyonnais, S., Gorelick, R.J., Mergny, J.L., LeCam, E., Mirambeau, G. (2003) G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA. Nucleic Acids Res. 31, 5754-5763.

  68. Guittat, L., Alberti, P., Rosu, F., Van Miert, S., Thetiot, E., Pieters, L., Gabelica, V., De Pauw, E., Ottaviani, A., Riou, J.F., Mergny, J.-L. (2003) Interactions of cryptolepine and neocryptolepine with unusual DNA structures. Biochimie 85, 535-547.

  69. Gomez, D., Aouali, N., Londono-Vallejo, A., Lacroix, L., Megnin-Chanet, F., Lemarteleur, T., Douarre, C., Shinya, K., Mailliet, P., Trentesaux, C., Morjani, H., Mergny, J.L., Riou, J.F. (2003) Resistance to the short term antiproliferative activity of the G-quadruplex ligand 12459 is associated with telomerase overexpression and telomere capping alteration. J. Biol. Chem. 278, 50554-50562.

  70. Alberti, P., Mergny, J.L. (2003) DNA duplex-quadruplex exchange as the basis for a nanomolecular machine. Proc. Natl. Acad. Sci. USA 100, 1569-1573.

  71. Alberti, P., Lacroix, L., Guittat, L., Hélène, C., Mergny, J.L. (2003) Nucleic acids as targets for antitelomerase agents. Mini Rev. Med. Chem. 3, 23-36.

  72. Riou, J.F., Guittat, L., Mailliet, P., Laoui, A., Petigenet, O., Megnin-Chanet, F., Hélène, C., Mergny, J.L. (2002) Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc. Natl. Acad. Sci. USA 99, 2672-2677.

  73. Phan, A.T., Mergny, J.L. (2002) Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res. 30, 4618-4625.

  74. Mills, M., Lacroix, L., Arimondo, P., Leroy, J.L., François, J.C., Klump, H.H., Mergny, J.L. (2002) Unusual DNA conformations: implications for telomeres. Curr. Med. Chem. Anti-Cancer Agents 2, 627-644.

  75. Mills, M., Arimondo, P., Lacroix, L., Garestier, T., Klump, H.H., Mergny, J.L. (2002) Chemical modification of the third strand : differential effects on Purine and Pyrimidine triple helix formation. Biochemistry 41, 357-366.

  76. Mergny, J.L., Riou, J.F., Mailliet, P., Teulade-Fichou, M.P., Gilson, E. (2002) Natural and Pharmacological regulation of telomerase. Nucleic Acids Res. 30, 839-865.

  77. Mergny, J.L., Lacroix, L. (2002) Des Tms, encore des Tms, toujours des Tms ! Regards/Biochimie 2, 36-52.

  78. Gomez, D., Mergny, J.L., Riou, J.F. (2002) Detection of Telomerase Inhibitors Based on G-Quadruplex Ligands by a Modified Telomeric Repeat Amplification Protocol Assay. Cancer Res. 62, 3365-3368. online Access

  79. Alberti, P., Schmidt, P., Nguyen, C.H., Hoarau, M., Grierson, D., Mergny, J.L. (2002) Benzoindoloquinolines interact with DNA quadruplexes and inhibit telomerase. Bioorg. Med. Chem. Lett. 12, 1071-7074.

  80. Alberti, P., Arimondo, P.B., Mergny, J.L., Garestier, T., Hélène, C., Sun, J.S. (2002) A directional nucleation-zipping mechanism for triple-helix formation. Nucleic Acids Res. 30, 5407-5415.

  81. Mergny, J.L., Maurizot, J.C. (2001) Fluorescence resonance energy transfer as a probe for G-quartet formation by a telomeric repeat. ChemBioChem 2, 124-132.

  82. Mergny, J.L., Lacroix, L., Teulade-Fichou, M.P., Hounsou, C., Guittat, L., Hoarau, M., Arimondo, P.B., Vigneron, J.P., Lehn, J.M., Riou, J.F., Garestier, T., Hélène, C. (2001) Telomerase inhibitors based on quadruplex ligands selected by a fluorescent assay. Proc. Natl. Acad. Sci. USA 98, 3062-3067.

  83. Koeppel, F., Riou, J.F., Laoui, A., Mailliet, P., Arimondo, P.B., Labit, D., Petigenet, O., Hélène, C., Mergny, J.L. (2001) Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes. Nucleic Acids Res. 29, 1087-1096.

  84. Guittat, L., Alberti, P., Mergny, J.-L., Riou, J.-F., Teulade-Fichou, M.-P., Mailliet, P. (2001) Inhibiteurs de la télomérase : conséquences pour la thérapeutique anticancéreuse. Médecine/Sciences 17, 1076-1081.

  85. Alberti, P., Ren, J., Teulade-Fichou, M.P., Guittat, L., Riou, J.F., Chaires, J.B., Hélène, C., Vigneron, J.P., Lehn, J.M., Mergny, J.L. (2001) Interaction of an acridine dimer with DNA quadruplex structures. J. Biomol. Struct. Dyn. 19, 505-513.

  86. Lacroix, L., Mergny, J.L. (2000) Chemical modification of pyrimidine TFOs: effect on i-motif and triple helix formation. Arch. Bioch. Biophys. 381, 153-163.

  87. Lacroix, L., Liénard, H., Labourier, E., Djavaheri, M., Lacoste, J., Tazi, J., Hélène, C., Mergny, J.L. (2000) Identification of two HeLa nuclear proteins that recognize the cytosine-rich strand of human telomeres in vitro. Nucleic Acids Res. 28, 1564-1575.

  88. Lacroix, L., Arimondo, P.B., Takasugi, M., Hélène, C., Mergny, J.L. (2000) Pyrimidine Morpholino Oligonucleotides Form a Stable Triple Helix in the Absence of Magnesium Ions. Biochem. Biophys. Res. Commun. 270, 363-369. online Access

  89. Arimondo, P., Riou, J.F., Mergny, J.L., Tazi, J., Sun, J.S., Garestier, T., Hélène, C. (2000) Interaction of human DNA topoisomerase I with intermolecular G-quartet structures. Nucleic Acids Res. 28, 4832-4838.

  90. Arimondo, P., Lacroix, L., Mills, M., Klump, H.H., François, J.C., Lacoste, J., Mergny, J.L. (2000) Conformations inhabituelles de l'ADN. Regards/Biochimie 25-37.

  91. Mills, M., Arimondo, P., Lacroix, L., Garestier, T., Hélène, C., Klump, H.H., Mergny, J.L. (1999) Energetics of strand displacement reactions in triple helices: a spectroscopic study. J. Mol. Biol. 291, 1035-1054.

  92. Mergny, J.L., Mailliet, P., Lavelle, F., Riou, J.F., Laoui, A., Hélène, C. (1999) The development of Telomerase inhibitors: The G-quartet approach. Anti Cancer Drug Des. 14, 327-339.

  93. Mergny, J.L. (1999) Fluorescence energy transfer as a probe for tetraplex formation: the i-motif. Biochemistry 38, 1573-1581.

  94. Liénard, H., Lacoste, J., Crépineau, F., Mergny, J.L. (1999) Recherche de protéines fixant des acides nucléiques par criblage de banques d'expression protéique. Regards/ Biochimie 48-56.

  95. Lacroix, L., Lacoste, J., Reddoch, J.F., Mergny, J.L., Levy, D.D., Seidman, M.M., Matteucci, M.D., Glazer, P.M. (1999) Triplex formation by oligonucleotides containing 5-(1-Propynyl)-2'- deoxyuridine: decreased magnesium dependence and improved intracellular gene targeting. Biochemistry 38, 1893-1901.

  96. Djavaheri-Mergny, M., Gras, M.P., Mergny, J.L., Dubertret, L. (1999) UV-A-induced decrease in nuclear factor-kappaB activity in human keratinocytes. Biochem. J. 338, 607-613. online Access

  97. Mergny, J.L., Phan, A.T., Lacroix, L. (1998) Following G-quartet formation by UV-spectroscopy. FEBS Lett. 435, 74-78.

  98. Mergny, J.L., Lacroix, L. (1998) Kinetics and Thermodynamics of i-DNA Formation: Phosphodiester vs. modified Oligodeoxynucleotides. Nucleic Acids Res. 26, 4797-4803.

  99. Mergny, J.L., Hélène, C. (1998) G-quadruplex DNA: A target for drug design. Nature Med. 4, 1366-1367.

  100. Lacroix, L., Mergny, J.L., Leroy, J.L., Hélène, C. (1996) Inability of RNA to form the i-motif: Implications for triplex formation. Biochemistry 35, 8715-8722.

  101. Faucon, B., Mergny, J.L., Hélène, C. (1996) Effect of third strand composition on triple helix formation: Purine versus pyrimidine oligodeoxynucleotides. Nucleic Acids Res. 24, 3181-3188.

  102. Mergny, J.L., Lacroix, L., Han, X., Leroy, J.L., Hélène, C. (1995) Intramolecular folding of pyrimidine oligodeoxynucleotides into an i-DNA motif. J. Am. Chem. Soc. 117, 8887-8898.

  103. Escudé, C., Nguyen, C.H., Mergny, J.L., Sun, J.S., Bisagni, E., Garestier, T., Hélène, C. (1995) Selective stabilization of DNA triple helices by benzopyridoindole derivatives. J. Am. Chem. Soc. 117, 10212-10219.

  104. Duval-Valentin, G., de Bizemont, T., Takasugi, M., Mergny, J.L., Bisagni, E., Hélène, C. (1995) Triple-helix specific ligands stabilize H-DNA conformation. J. Mol. Biol. 247, 847-858.

  105. Mergny, J.L., Garestier, T., Rougée, M., Lebedev, A.V., Chassignol, M., Thuong, N.T., Hélène, C. (1994) Fluorescence energy transfer between two triple helix-forming oligonucleotides bound to duplex DNA. Biochemistry 33, 15321-15328.

  106. Mergny, J.L., Djavaheri-Mergny, M. (1994) Le transfert d'énergie d'excitation en biologie. Regards sur la Biochimie 4, 17-27.

  107. Mergny, J.L., Boutorine, A.S., Garestier, T., Belloc, F., Rougée, M., Bulychev, N.V., Koshkin, A.A., Bourson, J., Lebedev, A.V., Valeur, B., Thuong, N.T., Hélène, C. (1994) Fluorescence Energy Transfer as a Probe for Nucleic Acid Structures and Sequences. Nucleic Acids Res. 22, 920-928.

  108. Leroy, J.L., Guéron, M., Mergny, J.L., Hélène, C. (1994) Intramolecular folding of a fragment of the cytosine-rich strand of telomeric DNA into an i-motif. Nucleic Acids Res. 22, 1600-1606.

  109. Belloc, F., Lacombe, F., Dumain, P., Mergny, J.L., Lopez, F., Bernard, P., Reiffers, J., Boisseau, M.R. (1993) Flow cytometric estimation of poly(A)+ RNA by fluorescent in situ hybridization. Cytometry 14, 339-343.

  110. Rougée, M., Faucon, B., Mergny, J.L., Barcelo, F., Giovannangeli, C., Garestier, T., Hélène, C. (1992) Kinetics and thermodynamics of triple-Helix formation: effects of ionic strength and mismatches. Biochemistry 31, 9269-9278.

  111. Mergny, J.L., Sun, J.S., Montenay-Garestier, T., Hélène, C. (1992) Fluorescent-oligodeoxynucleotide conjugates as probes of nucleic acids sequences and structures. J. Cell. Pharmacol. 3, 80-85.

  112. Mergny, J.L., Duval-Valentin, G., Nguyen, C.H., Perrouault, L., Faucon, B., Rougée, M., Montenay-Garestier, T., Bisagni, E., Hélène, C. (1992) Triple helix specific ligands. Science 256, 1691-1694.

  113. Sun, J.S., Mergny, J.L., Lavery, R., Montenay-Garestier, T., Hélène, C. (1991) Triple helix structures: sequence dependence, flexibility and mismatch effects. J. Biomol. Struct. Dyn. 9, 411-424.

  114. Mergny, J.L., Sun, J.S., Rougée, M., Montenay-Garestier, T., Barcelo, F., Chomilier, J., Hélène, C. (1991) Sequence specificity in triple helix formation: experimental and theoretical studies of the effect of mismatches on triplex stability. Biochemistry 30, 9791-9798.

  115. Mergny, J.L., Slama-Schwock, A., Rougée, M., Montenay-Garestier, T., Hélène, C. (1991) Fluorescence energy transfer between dimethyldiazaperopyrenium and ethidium bromide both intercalated into poly d(A-T). Photochem. Photobiol. 53, 555-558.

  116. Mergny, J.L., Collier, D., Rougée, M., Montenay-Garestier, T., Hélène, C. (1991) Intercalation of ethidium bromide in a triple-stranded oligonucleotide. Nucleic Acids Res. 19, 1521-1526.

  117. Collier, D.A., Mergny, J.L., Thuong, N.T., Hélène, C. (1991) Site-specific intercalation at the triplex-duplex junction induces a conformational change which is detectable by hypersensitivity to diethylpyrocarbonate. Nucleic Acids Res. 19, 4219-4224.

Jean-Louis Mergny

Jean-Louis Mergny

Research Director (INSERM)

Address
Institut Européen de Chimie et Biologie
INSERM U869
2 rue Robert Escarpit
33 607 Pessac
France

phone +33 540 003 022

fax +33 540 003 004